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What is Low Dose Naltrexone?

Naltrexone is commonly known as an opioid antagonist. At a daily dose of 50 mg by mouth, it has been shown to be effective in treating alcohol dependence and blocking the effects of opioids.

Low dose naltrexone (LDN) is a term for using naltrexone at a smaller dose, which is 5 mg or lower. The usual dose is 4.5 mg by mouth daily after being slowly increased from 1.5 mg once daily. The purpose of the slow increase is to help avoid initial side effects or predict if a lower dose is required. Common side effects include nausea and dizziness. Overall, low dose naltrexone is safe, tolerable, and effective for most patients. 

Low Dose Naltrexone has many off-label uses. Examples include:

  • Chronic pain and inflammation in autoimmune diseases.

    • Such as Crohn’s Disease, Fibromyalgia and Multiple Sclerosis.

  • Weight loss

  • Chronic fatigue syndrome

                                                                                  *This list is not all inclusive

Low dose naltrexone capsules are not commercially available and are made by a compounding pharmacy. At our compounding pharmacy, we use the pure active pharmaceutical ingredient (API) with the appropriate filler in clear capsule without dyes or extra additives. 

Talk to your doctor to see if LDN is for you. 

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